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Article

High content phenotypic cell-based visual screen identifies Mycobacterium tuberculosis acyltrehalose-containing glycolipids involved in phagosome remodeling.

PLoS pathogens - 9 Sept 2010

Brodin Priscille, Poquet Yannick, Levillain Florence, Peguillet Isabelle, Larrouy-Maumus Gerald, Gilleron Martine, Ewann Fanny, Christophe Thierry, Fenistein Denis, Jang Jichan, Jang Mi-Seon, Park Sei-Jin, Rauzier Jean, Carralot Jean-Philippe, Shrimpton Rachel, Genovesio Auguste, Gonzalo-Asensio Jesus A, Puzo Germain, Martin Carlos, Brosch Roland, Stewart Graham R, Gicquel Brigitte, Neyrolles Olivier

Abstract excerpt

The ability of the tubercle bacillus to arrest phagosome maturation is considered one major mechanism that allows its survival within host macrophages. To identify mycobacterial genes involved in this process, we developed a high throughput phenotypic cell-based assay enabling individual sub-cell...

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Source

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Identifiers

PMID: 20844580
DOI: 10.1371/journal.ppat.1001100
PMCID: PMC2936551

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20844580-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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