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An exacerbated phosphate starvation response triggers Mycobacterium tuberculosis glycerol utilization at acidic pH

29 Nov 2024

Abstract excerpt

ABSTRACT The mechanisms controlling Mycobacterium tuberculosis (Mtb) replication and survival inside its human host remain ill-defined. Phagosome acidification and nutrient deprivation are common mechanisms used by macrophages to restrict the replication of intracellular bacteria. Mtb stops replicating at mildly acidic pH ( pstA1 , a gene coding for a subunit of the Pst-1 system, results in the overexpression of...

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PMID: 39611843
DOI: 10.1128/mbio.02825-24

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