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Strategies in anti-Mycobacterium tuberculosis drug discovery based on phenotypic screening

10 Jul 2019

Abstract excerpt

The rise of multi- and extensively drug-resistant Mycobacterium tuberculosis (M. tb) strains and co-infection with human immunodeficiency virus has escalated the need for new anti-M. tb drugs. Numerous challenges associated with the M. tb, in particular slow growth and pathogenicity level 3, discouraged use of this organism in past primary screening efforts. From current knowledge of the physiology and drug...

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PMID: 31292530
DOI: 10.1038/s41429-019-0205-9

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