Article

Phagosomal acidification coordinates a lipid–redox program underlying antibiotic tolerance in Mycobacterium tuberculosis

2026-07-27

Abstract excerpt

<title>Abstract</title> Phenotypically drug-tolerant <italic>Mycobacterium tuberculosis</italic> ( <italic>Mtb</italic> ) subpopulations within macrophages delay bacterial clearance, contributing to prolonged therapy and treatment failure. Here, we identify phagosomal acidification as a metabolic control point linking host lipid metabolism, bacterial redox homeostasis, and antibiotic tolerance. Acidic ph...

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Literature Corpus work: 267e1926-9d8c-5b44-9a7d-b9d3472c2344
DOI: 10.21203/rs.3.rs-10290677/v1

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