Article

Genetic and metabolic regulation of <i>Mycobacterium tuberculosis</i> acid growth arrest

2017-09-09

Abstract excerpt

Mycobacterium tuberculosis (Mtb) senses and adapts to acidic environments during the course of infection. Acidic pH-dependent adaptations include the induction of metabolic genes associated with anaplerosis and growth arrest on specific carbon sources. In this study, reverse and forward genetic studies were undertaken to define new mechanisms underlying pH-dependent adaptations. Here we report that deletion of iso...

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Literature Corpus work: 4ef280fa-63ab-5617-b5ba-be868e9fc09d
DOI: 10.1101/186551

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