Article

Identifying a novel mechanism of L-leucine uptake in <i>Mycobacterium tuberculosis</i> using a chemical genomic approach

2025-04-14

Abstract excerpt

Amino acid biosynthesis is vital for Mycobacterium tuberculosis (Mtb) proliferation and tuberculosis pathogenesis. However, it is not clear how amino acids are transported in Mtb, particularly the branched chain amino acids (BCAAs) that contribute to the production of the cell-wall lipid component precursors such as acetyl-CoA and propionyl-CoA. While performing the screening of an FDA-approved repurposed librar...

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Literature Corpus work: 26fdcfc6-2f25-54fb-8831-efa03ee038ce
DOI: 10.1101/2025.04.14.648691

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