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Visualizing pyrazinamide action by live single cell imaging of phagosome acidification and <i>Mycobacterium tuberculosis</i> pH homeostasis

2021-12-20

Abstract excerpt

<h4>Summary</h4> The intracellular population of Mycobacterium tuberculosis (Mtb) is dynamically segregated within multiple subcellular niches with different biochemical and biophysical properties that, upon treatment, may impact antibiotic distribution, accumulation, and efficacy. However, it remains unclear whether fluctuating intracellular microenvironments alter mycobacterial homeostasis and contribute to an...

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Literature Corpus work
25036b9c-a302-598e-af0a-c484d7598253
DOI
10.1101/2021.12.20.473466
Open publication

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Visualizing pyrazinamide action by live single cell imaging of phagosome acidification and <i>Mycobacterium tuberculosis</i> pH homeostasisDOI 10.1101/2021.12.20.473466
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