Article
Mycobacterium tuberculosis diversity and macrophage heterogeneity dictate phagosomal acidification.
Microbiology spectrum - 1 Sept 2026
Chiacchiaretta Matteo, Sorrentino Rita, Bresciani Nadia, Aiello Alessandra, Vanini Valentina, Zambrano Samuel, Mazza Davide, Cugnata Federica, Cirillo Daniela Maria, Agresti Alessandra, Goletti Delia, Miotto Paolo
Abstract excerpt
Therapies counteracting pathogen-induced immune modulation of the host responses represent a promising improvement for tuberculosis treatments. Despite the documented role of host immune heterogeneity and bacterial genotypic background in determining infection outcomes, their interplay remains largely uncharacterized. We investigated the Mycobacterium tuberculosis (MTB)-human macrophage interaction, considering...
Read the complete abstract on PubMedTopics
- Phagosomes
- Mycobacterium tuberculosis
- Macrophages
- Humans
- Host-Pathogen Interactions