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Article

DiscoDivas: Leveraging genetic-ancestry continuum information to interpolate PRS for admixed populations.

American journal of human genetics - 2 Jul 2026

Ruan Yunfeng, Bhukar Rohan, Patel Aniruddh, Koyama Satoshi, Hull Leland, Truong Buu, Cho So Mi, Hornsby Whitney, Zhang Haoyu, Chatterjee Nilanjan, Natarajan Pradeep

Abstract excerpt

Genome-wide association study (GWAS) summary statistics for training and individual-level cohorts for fine-tuning are essential for constructing predictive polygenic risk score (PRS) models. However, the relatively low representation of admixed populations in both GWAS summary statistics and individual-level datasets hinders the development of PRSs and equitable clinical translation for admixed populations. Prior...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42235505
DOI: 10.1016/j.ajhg.2026.05.006
PMCID: PMC13504350

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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