Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cross-Ancestry Polygenic Prediction: Comparing Methods and Assessing Transferability Across Traits.

Genetic epidemiology - 1 Feb 2026

Momin Md Moksedul, Zhou Xuan, Ahmed Muktar, Hyppönen Elina, Benyamin Beben, Lee S Hong

Abstract excerpt

Accurate prediction of disease risk and other complex traits across different populations is essential for clinical and research purposes. However, genetic differences among ancestries, such as allelic frequencies and genetic architecture, can affect the performance of polygenic risk score (PGS) methods in cross-ancestry prediction. To address this issue, we conducted a formal test of seven polygenic prediction...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Height
Share to Body Mass Index
Share to Genetic Risk Score

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Models, Genetic

Share to Multifactorial Inheritance

Share to Prediction Algorithms

Share to UK Biobank

Source

Open in PubMed Open full text

Identifiers

PMID: 41562222
DOI: 10.1002/gepi.70029
PMCID: PMC12820924

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cross-Ancestry Polygenic Prediction: Comparing Methods and Assessing Transferability Across Traits.PMID 41562222Read ↗

Principles and methods for transferring polygenic risk scores across global populations.Semantic proximity Read ↗

BridgePRS leverages shared genetic effects across ancestries to increase polygenic risk score portability.Semantic proximity Read ↗

Leveraging local ancestry and cross-ancestry genetic architecture to improve genetic prediction of complex traits in admixed populations.Semantic proximity Read ↗

Quantifying portable genetic effects and improving cross-ancestry genetic prediction with GWAS summary statisticsSemantic proximity Read ↗

Quantifying portable genetic effects and improving cross-ancestry genetic prediction with GWAS summary statistics.Semantic proximity Read ↗

A method for an unbiased estimate of cross-ancestry genetic correlation using individual-level data.Semantic proximity Read ↗

PGS-server: accuracy, robustness and transferability of polygenic score methods for biobank scale studies.Semantic proximity Read ↗

Power of inclusion: Enhancing polygenic prediction with admixed individuals.Semantic proximity Read ↗

Polygenic scoring accuracy varies across the genetic ancestry continuum in all human populationsSemantic proximity Read ↗

Integrative polygenic risk score improves the prediction accuracy of complex traits and diseasesSemantic proximity Read ↗

Inclusion of Variants Discovered from Diverse Populations Improves Polygenic Risk Score TransferabilitySemantic proximity Read ↗

PRS-GRID: A Cross and Within Ancestry Polygenic Risk Prediction Method Based on Individual Genetic DistanceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.