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Article

Leveraging local ancestry and cross-ancestry genetic architecture to improve genetic prediction of complex traits in admixed populations.

American journal of human genetics - 7 Aug 2025

Zhou Geyu, Yolou Israel, Xie Yuhan, Zhao Hongyu

Abstract excerpt

The broader application of polygenic risk score (PRS) is hindered by the limited transferability of PRS developed in Europeans to non-European populations. While many statistical methods have been developed to improve the performance of PRS in non-European populations, most of them focused on discrete genetic ancestry clusters and did not consider admixed individuals. Admixed individuals pose a unique challenge...

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Identifiers

PMID: 40633541
DOI: 10.1016/j.ajhg.2025.06.010
PMCID: PMC12252582

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