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DiscoDivas: Leveraging genetic ancestry continuum information to interpolate PRS for admixed populations

2024-11-10

Abstract excerpt

<h4>Summary</h4> The relatively low representation of admixed populations in both discovery and fine-tuning individual-level datasets limits polygenic risk score (PRS) development and equitable clinical translation for admixed populations. Under the assumption that the most informative PRS model for a genetically homogeneous sample varies linearly in an ancestry continuum space, we introduce a Genetic Dis tance-...

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Literature Corpus work
31a8c899-b352-5c63-b3eb-a6298a145183
DOI
10.1101/2024.11.09.24316996
Open publication

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DiscoDivas: Leveraging genetic ancestry continuum information to interpolate PRS for admixed populationsDOI 10.1101/2024.11.09.24316996
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