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An Efficient Lasso Framework for Admixture-Aware Polygenic Scores

2025-08-27

Abstract excerpt

Polygenic scores (PGS) have promising clinical applications for risk stratification, disease screening, and personalized medicine. However, most PGS are trained on predominantly European ancestry cohorts and have limited portability to external populations. While cross-population PGS methods have demonstrated greater generalizability than single-ancestry PGS, they fail to properly account for individuals with rece...

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Literature Corpus work
c6b9335c-ac3b-588d-8d91-814e991cb379
DOI
10.1101/2025.08.26.671106
Open publication

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An Efficient Lasso Framework for Admixture-Aware Polygenic ScoresDOI 10.1101/2025.08.26.671106
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