Article

Polygenic scoring accuracy varies across the genetic ancestry continuum in all human populations

2022-09-29

Abstract excerpt

Polygenic scores (PGS) have limited portability across different groupings of individuals (e.g., by genetic ancestries and/or social determinants of health), preventing their equitable use. PGS portability has typically been assessed using a single aggregate population-level statistic (e.g., R 2 ), ignoring inter-individual variation within the population. Here we evaluate PGS accuracy at individual-level resolut...

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Literature Corpus work: a4b1a331-ddda-572a-a754-0b96b736c343
DOI: 10.1101/2022.09.28.509988

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