Article

S4-Multi: enhancing polygenic score prediction in ancestrally diverse populations

2025-01-27

Abstract excerpt

While polygenic scores (PGSs) have shown promise in advancing precision medicine by capturing the additive effects of common germline variants on inherited disease risk, they are presently limited by reduced performance outside of European-origin populations. We extend our previously developed Bayesian polygenic model (PGM) method, select and shrink with summary statistics (S4), to improve prediction accuracy in a...

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Literature Corpus work: 752ccdcb-9874-5059-bc42-8de6e601065e
DOI: 10.1101/2025.01.24.25321098

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