Article
An efficient LASSO framework for admixture-aware polygenic scores.
HGG advances - 9 Jul 2026
Ockerman Franklin, Chen Brian D, Sun Quan, Kharitonova Elena V, Chen Chang, Zhou Laura Y, Loos Ruth J F, Kooperberg Charles, Peters Ulrike, Haessler Jeffrey, Reiner Alexander P, Jung Su Yon, Manson JoAnn E, Nassir Rami, North Kari E, Buyske Steven, Haiman Christopher A, Conti David V, Wilkens Lynne R, Lange Ethan M, Cox Nancy J, Cao Hongyuan, Raffield Laura M, Li Yun, Tao Ran
Abstract excerpt
Polygenic scores (PGSs) have promising clinical applications for risk stratification, disease screening, and personalized medicine. However, most PGSs are trained on predominantly European ancestry cohorts and have limited portability to external populations. While cross-population PGSs have demonstrated greater generalizability than single-ancestry PGSs, they fail to properly account for individuals with recent...
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