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Article

Improving polygenic risk prediction in admixed populations by explicitly modeling ancestral-differential effects via GAUDI.

Nature communications - 3 Feb 2024

Sun Quan, Rowland Bryce T, Chen Jiawen, Mikhaylova Anna V, Avery Christy, Peters Ulrike, Lundin Jessica, Matise Tara, Buyske Steve, Tao Ran, Mathias Rasika A, Reiner Alexander P, Auer Paul L, Cox Nancy J, Kooperberg Charles, Thornton Timothy A, Raffield Laura M, Li Yun

Abstract excerpt

Polygenic risk scores (PRS) have shown successes in clinics, but most PRS methods focus only on participants with distinct primary continental ancestry without accommodating recently-admixed individuals with mosaic continental ancestry backgrounds for different segments of their genomes. Here, we develop GAUDI, a novel penalized-regression-based method specifically designed for admixed individuals. GAUDI...

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Identifiers

PMID: 38310129
DOI: 10.1038/s41467-024-45135-z
PMCID: PMC10838303

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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