Article

SPLENDID incorporates continuous genetic ancestry in biobank-scale data to improve polygenic risk prediction across diverse populations

2024-10-17

Abstract excerpt

Polygenic risk scores are widely used in disease risk stratification, but their accuracy varies across diverse populations. Recent methods large-scale leverage multi-ancestry data to improve accuracy in under-represented populations but require labelling individuals by ancestry for prediction. This poses challenges for practical use, as clinical practices are typically not based on ancestry. We propose SPLENDID, a...

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Literature Corpus work: 53e324a0-771a-5e89-992f-7ff66c50f3be
DOI: 10.1101/2024.10.14.618256

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