Article
Quantifying portable genetic effects and improving cross-ancestry genetic prediction with GWAS summary statistics.
Nature communications - 14 Feb 2023
Miao Jiacheng, Guo Hanmin, Song Gefei, Zhao Zijie, Hou Lin, Lu Qiongshi
Abstract excerpt
Polygenic risk scores (PRS) calculated from genome-wide association studies (GWAS) of Europeans are known to have substantially reduced predictive accuracy in non-European populations, limiting their clinical utility and raising concerns about health disparities across ancestral populations. Here, we introduce a statistical framework named X-Wing to improve predictive performance in ancestrally diverse...
Topics
- Humans
- Genome-Wide Association Study
- Polymorphism, Single Nucleotide
- Risk Factors
- Multifactorial Inheritance
- Genetic Predisposition to Disease