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Article

Quantifying portable genetic effects and improving cross-ancestry genetic prediction with GWAS summary statistics.

Nature communications - 14 Feb 2023

Miao Jiacheng, Guo Hanmin, Song Gefei, Zhao Zijie, Hou Lin, Lu Qiongshi

Abstract excerpt

Polygenic risk scores (PRS) calculated from genome-wide association studies (GWAS) of Europeans are known to have substantially reduced predictive accuracy in non-European populations, limiting their clinical utility and raising concerns about health disparities across ancestral populations. Here, we introduce a statistical framework named X-Wing to improve predictive performance in ancestrally diverse...

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Identifiers

PMID: 36788230
DOI: 10.1038/s41467-023-36544-7
PMCID: PMC9929290

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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