Article

Quantifying portable genetic effects and improving cross-ancestry genetic prediction with GWAS summary statistics

2022-05-29

Abstract excerpt

Polygenic risk scores (PRS) calculated from genome-wide association studies (GWAS) of Europeans are known to have substantially reduced predictive accuracy in non-European populations, limiting its clinical utility and raising concerns about health disparities across ancestral populations. Here, we introduce a novel statistical framework named X-Wing to improve predictive performance in ancestrally diverse populat...

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Literature Corpus work: 560b5a7b-b9b0-50bd-aed6-a4a6924d7184
DOI: 10.1101/2022.05.26.493528

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