Article

PRS-GRID: A Cross and Within Ancestry Polygenic Risk Prediction Method Based on Individual Genetic Distance

2024-05-16

Abstract excerpt

<h4>Background</h4> Two decades of genome-wide association studies (GWAS) have led to the fast-growing application of polygenic risk prediction (PRS). However, due to population structure and evolutionary path differences, the PRS substrate derived mostly from studies of European ancestry does not work equally well for other ancestries. There is an association between prediction accuracy decay and individual genet...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c8758ff8-2478-5dff-87b7-4a42de88ede2
DOI: 10.1101/2024.05.16.24307490

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

PRS-GRID: A Cross and Within Ancestry Polygenic Risk Prediction Method Based on Individual Genetic DistanceDOI 10.1101/2024.05.16.24307490Read

Cross-Ancestry Polygenic Prediction: Comparing Methods and Assessing Transferability Across Traits.Semantic proximity Read

DiscoDivas: Leveraging genetic ancestry continuum information to interpolate PRS for admixed populationsSemantic proximity Read

Benchmarking PRS methods for risk prediction of 36 complex traits in UK Biobank by establishment of a large-scale PRS computation platform PRS-hubSemantic proximity Read

Leveraging local ancestry and cross-ancestry genetic architecture to improve genetic prediction of complex traits in admixed populations.Semantic proximity Read

<i>PGSFusion</i> streamlines polygenic score construction and epidemiological applications in biobank-scale cohortsSemantic proximity Read

Multi-ethnic polygenic risk scores improve risk prediction in diverse populationsSemantic proximity Read

Principles and methods for transferring polygenic risk scores across global populations.Semantic proximity Read

Optimization of Multi-Ancestry Polygenic Risk Score Disease Prediction ModelsSemantic proximity Read

DiscoDivas: Leveraging genetic-ancestry continuum information to interpolate PRS for admixed populations.Semantic proximity Read

Inclusion of Variants Discovered from Diverse Populations Improves Polygenic Risk Score TransferabilitySemantic proximity Read

XPXP: improving polygenic prediction by cross-population and cross-phenotype analysis.Semantic proximity Read

Advancements and limitations in polygenic risk score methods for genomic prediction: a scoping review.Semantic proximity Read