Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nonuniform Association of Genetic Risk Scores for Intraocular Pressure.

JAMA ophthalmology - 1 Jun 2026

He Xi, Huang Yu, Plotnikov Denis, Terry Louise, Guggenheim Jeremy A

Abstract excerpt

Importance: Elevated intraocular pressure (IOP) is a risk factor for primary open-angle glaucoma, and genetic risk scores hold promise as a tool for screening for ocular hypertension. However, genetic risk scores for IOP have a nonuniform association across the range of IOP, which reduces their accuracy. Objective: To test the hypothesis that nonuniform behavior of genetic risk scores for IOP is associated with a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Cross-Sectional Studies
Share to Genetic Risk Score

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glaucoma, Open-Angle

Share to Intraocular Pressure

Share to Risk Factors

Share to Tonometry, Ocular

Share to UK Biobank

Source

Open in PubMed Open full text

Identifiers

PMID: 42060295
DOI: 10.1001/jamaophthalmol.2026.1022
PMCID: PMC13133721

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nonuniform Association of Genetic Risk Scores for Intraocular Pressure.PMID 42060295Read ↗

An Intraocular Pressure Polygenic Risk Score Stratifies Multiple Primary Open-Angle Glaucoma Parameters Including Treatment Intensity.Semantic proximity Read ↗

Polygenic risk score-based phenome-wide association for glaucoma and its impact on disease susceptibility in two large biobanks.Semantic proximity Read ↗

A large multi-ethnic genome-wide association study identifies novel genetic loci for intraocular pressure.Semantic proximity Read ↗

Genome-wide analyses identify 68 new loci associated with intraocular pressure and improve risk prediction for primary open-angle glaucoma.Semantic proximity Read ↗

Multi-trait Polygenic Probability Risk Score Enhances Glaucoma Prediction Across AncestriesSemantic proximity Read ↗

Glaucoma Polygenic Risk Scores Demonstrate Heterogeneous Performance across 2 Large Multiethnic Cohorts.Semantic proximity Read ↗

Polygenic Risk Scores Driving Clinical Change in Glaucoma.Semantic proximity Read ↗

Predictive Power of Polygenic Risk Scores for Intraocular Pressure or Vertical Cup-Disc Ratio.Semantic proximity Read ↗

Genome-wide association study of intraocular pressure uncovers new pathways to glaucoma.Semantic proximity Read ↗

Step change in glaucoma polygenic risk score performance enables clinical utility and disease prediction across all major ancestriesSemantic proximity Read ↗

Genetic architecture of open angle glaucoma and related determinants.Semantic proximity Read ↗

Polygenic Risk Score Improves Prediction of Primary Open Angle Glaucoma Onset in the Ocular Hypertension Treatment StudySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.