Article
Genome-wide analyses identify 68 new loci associated with intraocular pressure and improve risk prediction for primary open-angle glaucoma.
Nature genetics - 1 Jun 2018
Khawaja Anthony P, Cooke Bailey Jessica N, Wareham Nicholas J, Scott Robert A, Simcoe Mark, Igo Robert P, Song Yeunjoo E, Wojciechowski Robert, Cheng Ching-Yu, Khaw Peng T, Pasquale Louis R, Haines Jonathan L, Foster Paul J, Wiggs Janey L, Hammond Chris J, Hysi Pirro G
Abstract excerpt
Glaucoma is the leading cause of irreversible blindness globally 1 . Despite its gravity, the disease is frequently undiagnosed in the community 2 . Raised intraocular pressure (IOP) is the most important risk factor for primary open-angle glaucoma (POAG)3,4. Here we present a meta-analysis of 139,555 European participants, which identified 112 genomic loci associated with IOP, 68 of which are novel. These loci...
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