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Article

Polygenic Risk Scores Driving Clinical Change in Glaucoma.

Annual review of genomics and human genetics - 1 Aug 2024

Kolovos Antonia, Hassall Mark M, Siggs Owen M, Souzeau Emmanuelle, Craig Jamie E

Abstract excerpt

Glaucoma is a clinically heterogeneous disease and the world's leading cause of irreversible blindness. Therapeutic intervention can prevent blindness but relies on early diagnosis, and current clinical risk factors are limited in their ability to predict who will develop sight-threatening glaucoma. The high heritability of glaucoma makes it an ideal substrate for genetic risk prediction, with the bulk of risk...

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PMID: 38599222
DOI: 10.1146/annurev-genom-121222-105817

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