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Article

Glaucoma Polygenic Risk Scores Demonstrate Heterogeneous Performance across 2 Large Multiethnic Cohorts.

Ophthalmology. Glaucoma - 1 Jan 2026

Bineshfar Niloufar, Chen Liyin, Zhao Yan, Aziz Kanza, Zebardast Nazlee

Abstract excerpt

PURPOSE: Glaucoma is a leading cause of irreversible blindness. While polygenic risk scores (PRSs) have shown promise for patient risk stratification, their consistency and reliability across diverse populations remain insufficiently characterized. This study aimed to determine whether published glaucoma PRSs demonstrate consistent population-level performance and individual-level risk assignment in 2 large,...

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Identifiers

PMID: 41297607
DOI: 10.1016/j.ogla.2025.11.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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