Genome-wide association study of intraocular pressure uncovers new pathways to glaucoma.

doi:10.1038/s41588-018-0176-y

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Article

Genome-wide association study of intraocular pressure uncovers new pathways to glaucoma.

Nature genetics - 1 Aug 2018

MacGregor Stuart, Ong Jue-Sheng, An Jiyuan, Han Xikun, Zhou Tiger, Siggs Owen M, Law Matthew H, Souzeau Emmanuelle, Sharma Shiwani, Lynn David J, Beesley Jonathan, Sheldrick Bronwyn, Mills Richard A, Landers John, Ruddle Jonathan B, Graham Stuart L, Healey Paul R, White Andrew J R, Casson Robert J, Best Stephen, Grigg John R, Goldberg Ivan, Powell Joseph E, Whiteman David C, Radford-Smith Graham L, Martin Nicholas G, Montgomery Grant W, Burdon Kathryn P, Mackey David A, Gharahkhani Puya, Craig Jamie E, Hewitt Alex W

Abstract excerpt

Intraocular pressure (IOP) is currently the sole modifiable risk factor for primary open-angle glaucoma (POAG), one of the leading causes of blindness worldwide1. Both IOP and POAG are highly heritable2. We report a combined analysis of participants from the UK Biobank (n = 103,914) and previously published data from the International Glaucoma Genetic Consortium (n = 29,578)3,4 that identified 101 statistically...

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PMID: 30054594
DOI: 10.1038/s41588-018-0176-y

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