An Intraocular Pressure Polygenic Risk Score Stratifies Multiple Primary Open-Angle Glaucoma Parameters Including Treatment Intensity.

doi:10.1016/j.ophtha.2019.12.025

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Article

An Intraocular Pressure Polygenic Risk Score Stratifies Multiple Primary Open-Angle Glaucoma Parameters Including Treatment Intensity.

Ophthalmology - 1 Jul 2020

Qassim Ayub, Souzeau Emmanuelle, Siggs Owen M, Hassall Mark M, Han Xikun, Griffiths Helen L, Frost N Andrew, Vallabh Neeru A, Kirwan James F, Menon Geeta, Cree Angela J, Galanopoulos Anna, Agar Ashish, Healey Paul R, Graham Stuart L, Landers John, Casson Robert J, Gharahkhani Puya, Willoughby Colin E, Hewitt Alex W, Lotery Andrew J, MacGregor Stuart, Craig Jamie E

Abstract excerpt

PURPOSE: To examine the combined effects of common genetic variants associated with intraocular pressure (IOP) on primary open-angle glaucoma (POAG) phenotype using a polygenic risk score (PRS) stratification. DESIGN: Cross-sectional study. PARTICIPANTS: For the primary analysis, we examined the glaucoma phenotype of 2154 POAG patients enrolled in the Australian and New Zealand Registry of Advanced Glaucoma,...

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PMID: 32081492
DOI: 10.1016/j.ophtha.2019.12.025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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