Article
A large multi-ethnic genome-wide association study identifies novel genetic loci for intraocular pressure.
Nature communications - 13 Dec 2017
Choquet Hélène, Thai Khanh K, Yin Jie, Hoffmann Thomas J, Kvale Mark N, Banda Yambazi, Schaefer Catherine, Risch Neil, Nair K Saidas, Melles Ronald, Jorgenson Eric
Abstract excerpt
Elevated intraocular pressure (IOP) is a major risk factor for glaucoma, a leading cause of blindness. IOP heritability has been estimated to up to 67%, and to date only 11 IOP loci have been reported, accounting for 1.5% of IOP variability. Here, we conduct a genome-wide association study of IOP in 69,756 untreated individuals of European, Latino, Asian, and African ancestry. Multiple longitudinal IOP...
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