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Article

Predictive Power of Polygenic Risk Scores for Intraocular Pressure or Vertical Cup-Disc Ratio.

JAMA ophthalmology - 1 Jan 2025

He Weixiong, Lee Samantha Sze-Yee, Diaz Torres Santiago, Han Xikun, Gharahkhani Puya, Hunter Michael, Balartnasingam Chandrakumar, Craig Jamie E, Hewitt Alex W, Mackey David A, MacGregor Stuart

Abstract excerpt

Importance: Early detection of glaucoma is essential to timely monitoring and treatment, and primary open-angle glaucoma risk can be assessed by measuring intraocular pressure (IOP) or optic nerve head vertical cup-disc ratio (VCDR). Polygenic risk scores (PRSs) could provide a link between genetic effects estimated from genome-wide association studies (GWASs) and clinical applications to provide estimates of an...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39570582
DOI: 10.1001/jamaophthalmol.2024.4856
PMCID: PMC11583020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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