Article
Genetic architecture of open angle glaucoma and related determinants.
Journal of medical genetics - 1 Mar 2011
Ramdas Wishal D, Amin Najaf, van Koolwijk Leonieke M E, Janssens A Cecile J W, Demirkan Ayse, de Jong Paulus T V M, Aulchenko Yurii S, Wolfs Roger C W, Hofman Albert, Rivadeneira Fernando, Uitterlinden Andre G, Oostra Ben A, Lemij Hans G, Klaver Caroline C W, Vingerling Johannes R, Jansonius Nomdo M, van Duijn Cornelia M
Abstract excerpt
BACKGROUND: Although the vertical cup-disc ratio (VCDR) and intraocular pressure (IOP) are important determinants of open angle glaucoma (OAG), it is unclear to what extent the genetic origin of these traits overlap with those of OAG. We evaluated whether the same genes that determine VCDR and IOP also predict OAG. METHODS: Genetic risk scores were constructed from single nucleotide polymorphisms (SNPs) using...
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