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Does Age Modify the Relation Between Genetic Predisposition to Glaucoma and Various Glaucoma Traits in the UK Biobank?

Investigative ophthalmology & visual science - 3 Feb 2025

Kim Jihye, Kang Jae H, Wiggs Janey L, Zhao Hetince, Li Keva, Zebardast Nazlee, Segrè Ayellet, Friedman David S, Do Ron, Khawaja Anthony P, Aschard Hugues, Pasquale Louis R

Abstract excerpt

Purpose: Glaucoma polygenic risk scores could guide glaucoma public health screening initiatives. We investigated how age influences the relationship between a multitrait glaucoma polygenic risk score (mtGPRS) and primary open-angle glaucoma indicators, including intraocular pressure (IOP), retinal structure, and glaucoma prevalence. Methods: We analyzed UK Biobank participants with demographic and genetic data,...

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Identifiers

PMID: 39982391
DOI: 10.1167/iovs.66.2.57
PMCID: PMC11855177

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