Article

Multi-trait Polygenic Probability Risk Score Enhances Glaucoma Prediction Across Ancestries

2025-03-28

Abstract excerpt

Primary open-angle glaucoma (POAG) remains the leading cause of irreversible blindness worldwide, with early detection crucial for preventing vision loss. However, current risk assessment methods have limited predictive power. Here, we present a multi-trait polygenic probability risk score (PPRS) approach that integrates multiple glaucoma-related traits and leverages functional genomic annotations to enhance POAG...

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Literature Corpus work: 0393bb09-85f8-5c79-8971-52e162b0b1cd
DOI: 10.1101/2025.03.27.25324762

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