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Article

Polygenic risk score-based phenome-wide association for glaucoma and its impact on disease susceptibility in two large biobanks.

Journal of translational medicine - 15 Apr 2024

Yun Jae-Seung, Jung Sang-Hyuk, Lee Su-Nam, Jung Seung Min, Won Hong-Hee, Kim Dokyoon, Choi Jin A

Abstract excerpt

BACKGROUND: Glaucoma is a leading cause of worldwide irreversible blindness. Considerable uncertainty remains regarding the association between a variety of phenotypes and the genetic risk of glaucoma, as well as the impact they exert on the glaucoma development. METHODS: We investigated the associations of genetic liability for primary open angle glaucoma (POAG) with a wide range of potential risk factors and to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38622600
DOI: 10.1186/s12967-024-05152-4
PMCID: PMC11020996

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