Article

Step change in glaucoma polygenic risk score performance enables clinical utility and disease prediction across all major ancestries

2026-01-24

Abstract excerpt

<h4>SUMMARY</h4> Glaucoma is the leading cause of irreversible blindness; vision loss is preventable with timely treatment, but early detection is challenging, leaving ∼50% undiagnosed, highlighting the need for improved risk assessment tools. We developed a polygenic risk score (PRS) using data from >6 million individuals. PRS performance was exceptional in European ancestries; top 10% PRS individuals had 10-fol...

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Literature Corpus work: 28ea6bc3-4421-5efb-adff-ead2c4cbba24
DOI: 10.64898/2026.01.23.26344675

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