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Article

Clonal evolution patterns in acute myeloid leukemia with NPM1 mutation

2 May 2019

Abstract excerpt

Abstract Mutations in thenucleophosmin 1(NPM1) gene are considered founder mutations in the pathogenesis of acute myeloid leukemia (AML). To characterize the genetic composition ofNPM1mutated (NPM1mut) AML, we assess mutation status of five recurrently mutated oncogenes in 129 pairedNPM1mutsamples obtained at diagnosis and relapse. We find a substantial shift in the genetic pattern from diagnosis to relapse...

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PMID: 31048683
DOI: 10.1038/s41467-019-09745-2

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