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Article

Clonal Metamorphosis: Deconstructing MPN Evolution with Single-Cell and Spatial Multi-Omics.

Clinical and experimental medicine - 29 Jun 2026

Iqbal Muhammad Shahid, Alahmari Abdullah K, Khan Mohd Faiyaz, Farooqui Sadaf, Iqbal Muhammad Zahid, Khan Salah-Ud-Din, Khan Nazia, Seshadri Vidya Devanathadesikan, Abdelgawwad El-Sehrawy Amr Ali Mohamed

Abstract excerpt

Myeloproliferative neoplasms (MPNs) present a fundamental paradox: despite sharing a small set of canonical driver mutations in JAK2, CALR, or MPL, patients exhibit striking heterogeneity in disease latency, clinical presentation, and evolutionary trajectories to myelofibrosis or secondary acute myeloid leukemia. This review synthesizes recent advances in single-cell and spatial multi-omic technologies that are...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42371175
DOI: 10.1007/s10238-026-02246-9
PMCID: PMC13320090

Genes

CALR
JAK2
MPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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