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Article

GRPa-PRS: A risk stratification method to identify genetically-regulated pathways in polygenic diseases.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Oct 2025

Li Xiaoyang, Fernandes Brisa S, Liu Andi, Chen Jingchun, Chen Xiangning, Zhao Zhongming, Dai Yulin

Abstract excerpt

INTRODUCTION: Polygenic risk score (PRS) assesses genetic risk for diseases, yet some high-risk individuals avoid illness while low-risk individuals develop it. We hypothesize that unknown counterfactors may reverse PRS predictions, offering insights into disease mechanisms and interventions. METHODS: We developed a novel framework to identify genetically-regulated pathways (GRPas) using PRS-based stratification...

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Identifiers

PMID: 41085130
DOI: 10.1002/alz.70779
PMCID: PMC12519521

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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