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Article

Pathway-Specific Polygenic Risk Scores Correlate with Clinical Status and Alzheimer's Disease-Related Biomarkers.

Journal of Alzheimer's disease : JAD - 1 Jan 2023

Schork Nicholas J, Elman Jeremy A

Abstract excerpt

BACKGROUND: APOE is the largest genetic risk factor for Alzheimer's disease (AD), but there is a substantial polygenic component. Polygenic risk scores (PRS) can summarize small effects across the genome but may obscure differential risk across molecular processes and pathways that contribute to heterogeneity of disease presentation. OBJECTIVE: We examined polygenic risk impacting specific AD-associated pathways...

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Identifiers

PMID: 37661888
DOI: 10.3233/JAD-230548
PMCID: PMC10697039

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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