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Article

Integrative multi-omics approaches identify molecular pathways and improve Alzheimer's disease risk prediction.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Nov 2025

Venkatesh Rasika, Cardone Katie M, Bradford Yuki, Moore Anni K, Kumar Rachit, Moore Jason H, Shen Li, Kim Dokyoon, Ritchie Marylyn D

Abstract excerpt

INTRODUCTION: Alzheimer's disease (AD) is a complex neurodegenerative disorder with heterogeneous genetic and molecular underpinnings. Polygenic scores (PGS) capture little of this complexity. METHODS: We conducted genome-, transcriptome-, and proteome-wide association studies (G/T/PWAS) on 15,480 individuals from the Alzheimer's Disease Sequencing Project R4 (ADSP) to identify AD-associated signals, followed by...

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PMID: 41231230
DOI: 10.1002/alz.70886
PMCID: PMC12614089

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