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Article

From Polygenic Scores to Precision Medicine in Alzheimer's Disease: A Systematic Review.

Journal of Alzheimer's disease : JAD - 1 Jan 2020

Harrison Judith R, Mistry Sumit, Muskett Natalie, Escott-Price Valentina

Abstract excerpt

BACKGROUND: Late-onset Alzheimer's disease (AD) is highly heritable. The effect of many common genetic variants, single nucleotide polymorphisms (SNPs), confer risk. Variants are clustered in areas of biology, notably immunity and inflammation, cholesterol metabolism, endocytosis, and ubiquitination. Polygenic scores (PRS), which weight the sum of an individual's risk alleles, have been used to draw inferences...

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Identifiers

PMID: 32250305
DOI: 10.3233/JAD-191233
PMCID: PMC7242840

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