Article

Pathway-specific polygenic risk scores correlate with clinical status and Alzheimer’s-related biomarkers

2023-03-01

Abstract excerpt

<title>Abstract</title><p><bold>Background:</bold><italic>APOE</italic>is the largest genetic risk factor for sporadic Alzheimer’s disease (AD), but there is a substantial polygenic component as well. Polygenic risk scores (PRS) can summarize small effects across the genome but may obscure differential risk associated with different molecular processes and pathways. Variability at the genetic level may contribute...

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Literature Corpus work: 90ce7ea7-9290-5fb1-abf4-6daf18d537e4
DOI: 10.21203/rs.3.rs-2583037/v1

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