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Article

Golgi apparatus, endoplasmic reticulum and mitochondrial function implicated in Alzheimer's disease through polygenic risk and RNA sequencing.

Molecular psychiatry - 1 Mar 2023

Crawford Karen, Leonenko Ganna, Baker Emily, Grozeva Detelina, Lan-Leung Benoit, Holmans Peter, Williams Julie, O'Donovan Michael C, Escott-Price Valentina, Ivanov Dobril K

Abstract excerpt

Polygenic risk scores (PRS) have been widely adopted as a tool for measuring common variant liability and they have been shown to predict lifetime risk of Alzheimer's disease (AD) development. However, the relationship between PRS and AD pathogenesis is largely unknown. To this end, we performed a differential gene-expression and associated disrupted biological pathway analyses of AD PRS vs. case/controls in...

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Identifiers

PMID: 36577842
DOI: 10.1038/s41380-022-01926-8
PMCID: PMC10005937

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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