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Effect of Pathway-specific Polygenic Risk Scores for Alzheimer’s Disease (AD) on Rate of Change in Cognitive Function and AD-related Biomarkers among Asymptomatic Individuals

2023-02-01

Abstract excerpt

<h4>Background</h4> Genetic scores for late-onset Alzheimer’s disease (LOAD) have been associated with preclinical cognitive decline and biomarker variations. Compared with an overall polygenic risk score (PRS), a pathway-specific PRS (p-PRS) may be more appropriate in predicting a specific biomarker or cognitive component underlying LOAD pathology earlier in the lifespan. <h4>Objective</h4> In this study, we le...

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Literature Corpus work
a4ffe46e-34d0-535d-9a4d-7c0422b69b82
DOI
10.1101/2023.01.30.23285142
Open publication

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Effect of Pathway-specific Polygenic Risk Scores for Alzheimer’s Disease (AD) on Rate of Change in Cognitive Function and AD-related Biomarkers among Asymptomatic IndividualsDOI 10.1101/2023.01.30.23285142
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