Article
Genetic variants and functional pathways associated with resilience to Alzheimer's disease.
Brain : a journal of neurology - 1 Aug 2020
Dumitrescu Logan, Mahoney Emily R, Mukherjee Shubhabrata, Lee Michael L, Bush William S, Engelman Corinne D, Lu Qiongshi, Fardo David W, Trittschuh Emily H, Mez Jesse, Kaczorowski Catherine, Hernandez Saucedo Hector, Widaman Keith F, Buckley Rachel, Properzi Michael, Mormino Elizabeth, Yang Hyun-Sik, Harrison Tessa, Hedden Trey, Nho Kwangsik, Andrews Shea J, Tommet Doug, Hadad Niran, Sanders R Elizabeth, Ruderfer Douglas M, Gifford Katherine A, Moore Annah M, Cambronero Francis, Zhong Xiaoyuan, Raghavan Neha S, Vardarajan Badri, Pericak-Vance Margaret A, Farrer Lindsay A, Wang Li-San, Cruchaga Carlos, Schellenberg Gerard, Cox Nancy J, Haines Jonathan L, Keene C Dirk, Saykin Andrew J, Larson Eric B, Sperling Reisa A, Mayeux Richard, Bennett David A, Schneider Julie A, Crane Paul K, Jefferson Angela L, Hohman Timothy J
Abstract excerpt
Approximately 30% of older adults exhibit the neuropathological features of Alzheimer's disease without signs of cognitive impairment. Yet, little is known about the genetic factors that allow these potentially resilient individuals to remain cognitively unimpaired in the face of substantial neuropathology. We performed a large, genome-wide association study (GWAS) of two previously validated metrics of cognitive...
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