Article
Polygenic resilience scores capture protective genetic effects for Alzheimer's disease.
Translational psychiatry - 25 Jul 2022
Hou Jiahui, Hess Jonathan L, Armstrong Nicola, Bis Joshua C, Grenier-Boley Benjamin, Karlsson Ida K, Leonenko Ganna, Numbers Katya, O'Brien Eleanor K, Shadrin Alexey, Thalamuthu Anbupalam, Yang Qiong, Andreassen Ole A, Brodaty Henry, Gatz Margaret, Kochan Nicole A, Lambert Jean-Charles, Laws Simon M, Masters Colin L, Mather Karen A, Pedersen Nancy L, Posthuma Danielle, Sachdev Perminder S, Williams Julie, Fan Chun Chieh, Faraone Stephen V, Fennema-Notestine Christine, Lin Shu-Ju, Escott-Price Valentina, Holmans Peter, Seshadri Sudha, Tsuang Ming T, Kremen William S, Glatt Stephen J
Abstract excerpt
Polygenic risk scores (PRSs) can boost risk prediction in late-onset Alzheimer's disease (LOAD) beyond apolipoprotein E (APOE) but have not been leveraged to identify genetic resilience factors. Here, we sought to identify resilience-conferring common genetic variants in (1) unaffected individuals having high PRSs for LOAD, and (2) unaffected APOE-ε4 carriers also having high PRSs for LOAD. We used genome-wide...
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