Article

Polygenic resilience scores capture protective genetic effects for Alzheimer’s disease

2022-05-10

Abstract excerpt

Polygenic risk scores (PRSs) can boost risk-prediction in late-onset Alzheimer’s disease (LOAD) beyond apolipoprotein E ( APOE) but have not been leveraged to identify genetic resilience factors. Here, we sought to identify resilience-conferring common genetic variants in 1) unaffected individuals having high PRSs for LOAD, and 2) unaffected APOE - ε 4 carriers also having high PRSs for LOAD. We used genome-wide a...

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Literature Corpus work: f9323a38-7dce-5df4-99cd-325e761aa3de
DOI: 10.1101/2022.05.10.22274858

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