Article
PICALM Alzheimer's risk allele causes aberrant lipid droplets in microglia.
Nature - 1 Oct 2025
Kozlova Alena, Zhang Siwei, Sudwarts Ari, Zhang Hanwen, Smirnou Stanislau, Byeon Seul Kee, Thapa Christina, Sun Xiaotong, Stephenson Kimberley, Zhao Xiaojie, Jamison Brendan, Ponnusamy Moorthi, He Xin, Schneider Julie A, Pandey Akhilesh, Bennett David A, Pang Zhiping P, Sanders Alan R, Bellen Hugo J, Thinakaran Gopal, Duan Jubao
Abstract excerpt
Despite genome-wide association studies (GWAS) of late-onset Alzheimer's disease (LOAD) having identified many genetic risk loci1-3, the underlying disease mechanisms remain largely unclear. Determining causal disease variants and their LOAD-relevant cellular phenotypes has been a challenge. Here, using our approach for identifying functional GWAS risk variants showing allele-specific open chromatin, we...
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