Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An integrated genome and phenome-wide association study approach to understanding Alzheimer's disease predisposition.

Neurobiology of aging - 1 Oct 2022

Khaire Archita S, Wimberly Courtney E, Semmes Eleanor C, Hurst Jillian H, Walsh Kyle M

Abstract excerpt

Genome-wide association studies (GWAS) have identified common single nucleotide polymorphisms (SNPs) that increase late-onset Alzheimer's disease (LOAD) risk. To identify additional LOAD-associated variants and provide insight into underlying disease biology, we performed a phenome-wide association study on 23 known LOAD-associated SNPs and 4:1 matched control SNPs using UK Biobank data. LOAD-associated SNPs were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Alzheimer's disease research and treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenetics and DNA Methylation

Share to ErbB Receptors

Share to Genetic Associations and Epidemiology

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 35715361
DOI: 10.1016/j.neurobiolaging.2022.05.011
PMCID: PMC9787699

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An integrated genome and phenome-wide association study approach to understanding Alzheimer's disease predisposition.PMID 35715361Read ↗

An integrated genome and phenome-wide association study approach to understanding Alzheimer’s disease predispositionSemantic proximity Read ↗

PICALM Alzheimer's risk allele causes aberrant lipid droplets in microglia.Semantic proximity Read ↗

Alzheimer’s disease risk allele of PICALM causes detrimental lipid droplets in microgliaSemantic proximity Read ↗

Late-Onset Alzheimer’s Disease Genes and the Potentially Implicated PathwaysSemantic proximity Read ↗

Genetic variants influencing human aging from late-onset Alzheimer's disease (LOAD) genome-wide association studies (GWAS).Semantic proximity Read ↗

Data mining of high density genomic variant data for prediction of Alzheimer's disease risk.Semantic proximity Read ↗

Association of Variants in PINX1 and TREM2 With Late-Onset Alzheimer DiseaseSemantic proximity Read ↗

Genome-wide association study of Alzheimer's disease.Semantic proximity Read ↗

Whole-exome sequencing of the BDR cohort: evidence to support the role of the PILRA gene in Alzheimer's disease.Semantic proximity Read ↗

Meta-analysis of genetic association with diagnosed Alzheimer’s disease identifies novel risk loci and implicates Abeta, Tau, immunity and lipid processingSemantic proximity Read ↗

Genome-wide association of polygenic risk extremes for Alzheimer's disease in the UK Biobank.Semantic proximity Read ↗

Large-scale Rare Variant Burden Testing in Parkinson’s Disease Identifies Novel Associations with Genes Involved in Neuro-inflammationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.