APOE4/4 is linked to damaging lipid droplets in Alzheimer's disease microglia.

doi:10.1038/s41586-024-07185-7

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Article

APOE4/4 is linked to damaging lipid droplets in Alzheimer's disease microglia.

Nature - 1 Apr 2024

Haney Michael S, Pálovics Róbert, Munson Christy Nicole, Long Chris, Johansson Patrik K, Yip Oscar, Dong Wentao, Rawat Eshaan, West Elizabeth, Schlachetzki Johannes C M, Tsai Andy, Guldner Ian Hunter, Lamichhane Bhawika S, Smith Amanda, Schaum Nicholas, Calcuttawala Kruti, Shin Andrew, Wang Yung-Hua, Wang Chengzhong, Koutsodendris Nicole, Serrano Geidy E, Beach Thomas G, Reiman Eric M, Glass Christopher K, Abu-Remaileh Monther, Enejder Annika, Huang Yadong, Wyss-Coray Tony

Abstract excerpt

Several genetic risk factors for Alzheimer's disease implicate genes involved in lipid metabolism and many of these lipid genes are highly expressed in glial cells1. However, the relationship between lipid metabolism in glia and Alzheimer's disease pathology remains poorly understood. Through single-nucleus RNA sequencing of brain tissue in Alzheimer's disease, we have identified a microglial state defined by the...

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Identifiers

PMID: 38480892
DOI: 10.1038/s41586-024-07185-7
PMCID: PMC10990924

Genes

ACSL1
APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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