Article

MEF2C controls lysosomal and lipid clearance programs linked to Alzheimer’s disease risk in macrophages

2026-04-28

Abstract excerpt

<title>Abstract</title> <p>Risk alleles for late-onset Alzheimer’s disease (AD) are enriched in myeloid cis-regulatory elements, implicating myeloid gene-regulatory networks in disease susceptibility. A conserved lipid-associated transcriptional signature—spanning disease-associated microglia and peripheral lipid-associated macrophages (DLAM)—emerges across neurodegenerative and metabolic diseases characterized b...

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Literature Corpus work: cf82f12a-a935-5f90-ab02-f8d1cc9f8649
DOI: 10.21203/rs.3.rs-9164252/v1

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